Chloropeptins, new Anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I

Abstract

The structure of chloropeptin I, a gp120-CD4 binding inhibitor having a potent anti-HIV activity, was elucidated by 1H and 13C NMR experiments and chemical degradation. It is a peptide antibiotic consisting of six aryl amino acids residues and an α-oxo aryl acid some of which have chlorine atoms.