Systemic Inflammatory Disease and AMD Comorbidity

Abstract

Prevalence of age-related macular degeneration (AMD), the leading cause of blindness in the United States, increases greatly with age. While age is the greatest risk factor of AMD, other risks such as smoking, family history, complement pathway activation, and race exist. Various systemic inflammatory diseases share many of these risk factors with AMD, as well as a similar inflammatory profile. Due to these similarities, patient database studies analyzing the association between patients with various systemic diseases and AMD have been performed. In this review we will summarize recent finding on this subject and discuss the implications on AMD diagnosis. By gaining greater insight into the association between chronic systemic inflammation and AMD, implications for novel therapeutic approaches to treat AMD pathology may be identified.