Safety, efficacy, and analysis of key parameters after prophylactic administration of a sustained-release formulation of azithromycin in lung cancer surgery

2Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

Background: The current use of prophylactic antibiotics for lung cancer surgery requires modification in aging individuals with impaired lung function. A sustained-release formulation of azithromycin (AZM-SR) could help resolve some of these challenges with its sustained antibacterial and anti-inflammatory effects. The aim of this study was to examine the safety and efficacy of AZM-SR in lung cancer surgery as well as its anti-inflammatory effect. Methods: Fifty patients were included in the study, and AZM-SR was administered 1 day prior to the surgery. The clinical course, including postoperative complications, was monitored, and the concentration of AZM, bacterial culture, and inflammatory cytokine levels of resected lung specimens were evaluated. Results: No side effects related to AZM-SR were observed. Five cases of postoperative pneumonia (10%) were observed; technical issues were involved in 3 cases. All patients recovered well. Four cases showed positive bacterial culture upon lung tissue examination; however, this was not significantly correlated with postoperative complications. A negative correlation was observed between AZM concentration in lung tissue and interleukin-6 (IL-6) expression. Conclusions: Prophylactic utilization of AZM-SR in lung cancer surgery seems feasible. The anti-inflammatory effect of AZM might contribute additional beneficial effects in the perioperative management of lung cancer surgery.

References Powered by Scopus

Azithromycin for prevention of exacerbations of COPD

1059Citations
N/AReaders
Get full text

Azithromycin: Mechanisms of action and their relevance for clinical applications

490Citations
N/AReaders
Get full text

Azithromycin induces anti-viral responses in bronchial epithelial cells

254Citations
N/AReaders
Get full text

Cited by Powered by Scopus

A mini-review on anticancer-related properties of azithromycin and its potential activities in overcoming the challenges of glioblastoma

5Citations
N/AReaders
Get full text

Antibiotic adoption effects on nutrition and quality of life in lung cancer patients undergoing radiotherapy and chemotherapy: A meta-analysis

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Taniguchi, D., Watanabe, H., Morinaga, Y., Sasaki, D., Matsuda, J., Sato, S., … Nagayasu, T. (2021). Safety, efficacy, and analysis of key parameters after prophylactic administration of a sustained-release formulation of azithromycin in lung cancer surgery. Annals of Palliative Medicine, 10(5), 5098–5107. https://doi.org/10.21037/apm-21-383

Readers' Seniority

Tooltip

Researcher 1

100%

Readers' Discipline

Tooltip

Nursing and Health Professions 3

75%

Immunology and Microbiology 1

25%

Save time finding and organizing research with Mendeley

Sign up for free