HCC is a rapidly increasing cancer worldwide. Most HCC rises in the setting of chronic and advanced liver disease caused by viral hepatitis, alcohol use, non-alcoholic liver disease or their combination. We found that in the mouse model, alcohol alone does not induce HCC, however, it can promote HCC development after a carcinogen exposure. Multiple mechanisms are involved in carcinogenesis and alcohol affects many of those including epithelial-mesenchymal transition, cancer stem marker expression and inflammation as evidenced in our HCC model.
CITATION STYLE
Szabo, G. (2018). Alcoholic liver disease accelerates early hepatocellular cancer in amouse model. In Advances in Experimental Medicine and Biology (Vol. 1032, pp. 71–79). Springer New York LLC. https://doi.org/10.1007/978-3-319-98788-0_5
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