31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Abstract

The proceedings contain 435 papers. The topics discussed include: incidence and outcomes of central nervous system metastasis in metastatic melanoma patients treated with anti-PD-1 therapy; converting tumor-mediated PD-L1 inhibition into CAR T cell costimulation to potentiate adoptive T cell therapy; neuropilin-1-deficient regulatory T cell-derived interferon-gamma drives infectious instability and tumor clearance; engineering 2nd generation SPEAR T cells to overcome TGF-beta-mediated immunosuppression for adoptive cell therapy; inducible MyD88/CD40 (iMC) costimulation drives liganddependent tumor eradication by CD123-specific chimeric antigen receptor T cells; heterodimeric IL-15 treatment enhances tumor infiltration, persistence and effector functions of adoptively transferred tumor-specific T cells in the absence of lymphodepletion; peptide vaccine enhances antitumor effect of adoptive cell transfer using genetically engineered T cells; partially differentiated polyfunctional T cells dominate the periphery after tumor-infiltrating lymphocytes therapy for cancer; stable tumor-infiltrating lymphocytes (TIL) phenotype following cryopreservation; bioluminescent redirected lysis assay (BRLA) as an efficient potency assay to assess tumor-infiltrating lymphocytes (TILs) for immunotherapy; and culturing and live cell confocal imaging of ovarian cancer spheroids with monocytes and interferons.