Coordinated Sequence Replays Between the Visual Cortex and Hippocampus

Abstract

Based on our previously published study, in this chapter, we discuss the interaction between the hippocampus (CA1) and primary visual cortex (V1) in the acquisition and consolidation of memories with an emphasis upon how this study supports, and expands upon, contemporary memory theories. Both CA1 and V1 neurons were shown to contribute to the acquisition of hippocampal-dependent epi-sodic memory and to the memory consolidation process during slow-wave sleep. V1 neurons also participate in hippocampal-independent remote memory function following consolidation. Thus, V1 neurons appear to be tuned to both external stim-uli and internal memories. These data not only support key elements of contempo-rary memory theories but also provide fresh, new insights into the consolidation process. Our fi ndings also raise important questions with regard to the distinctions between sensory and memory circuits.