New approach for the electrochemical detection of dopamine

Abstract

An innovative biomimeric electrochemical sensor was elaborated for the dopamine detection using a glassy carbon electrode modified with gold nanoparticles. The molecularly imprinted polymers and nonimprinted polymers were electro- chemically generated on the electrode surface after the obtaining of the self-assembled monolayer of the functional monomer -p-aminothiophenol through sulfur-gold bonds with dopamine as template molecule (in the case of molecularly imprinted polymer). Cyclic voltammetry and electrochemical impedance spectroscopy were used for the characterization of the sensor considering its response in the presence of hexacy-anoferrate as redox probe, while the morphostructural characterization of the elaborated platform was realized by using atomic force microscopy. Differential pulse voltammetry experiments in saline phosphate buffer (0.02M; pH 7.4) were performed after the preconcentration of dopamine in order to test the biomimetic sensor performance.