Production of Ac-225 with cyclotrons for generating Bi-213 for targeted alpha therapy

Abstract

By making use of our isotope production yield curves we have estimated the production of Ac-225, the mother nuclide of Bi-213, through (p,2n) and (d,3n) reactions on Ra-226. It is shown that, from a thick Ra-226 target, Ac-225 yields of 1.1 x 1010, 1.9 x 1010 and 2.1 x 1010 Bq can be obtained at proton bombarding energies of 20, 30 and 34 MeV respectively at an incident beam intensity of 100 μA and irradiation time of only one day. Similarly the yields of Ac-225 through the (d,3n) reaction on a thick target of Ra-226 have also been estimated to be 4.2 x 109, 1.1 x 10 10 and 1.4 x 1010 Bq respectively at deuteron energies of 20, 30 and 34 MeV and beam intensity of 100 μA and irradiation time of one day. © 2009 Springer-Verlag.