Calcium Buffering in the Heart in Health and Disease

4Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

Changes of intracellular Ca2+ concentration regulate many aspects of cardiac myocyte function. About 99% of the cytoplasmic calcium in cardiac myocytes is bound to buffers, and their properties will therefore have a major influence on Ca2+ signaling. This article considers the fundamental properties and identities of the buffers and how to measure them. It reviews the effects of buffering on the systolic Ca2+ transient and how this may change physiologically, and in heart failure and both atrial and ventricular arrhythmias, as well. It is concluded that the consequences of this strong buffering may be more significant than currently appreciated, and a fuller understanding is needed for proper understanding of cardiac calcium cycling and contractility.

Cite

CITATION STYLE

APA

Smith, G. L., & Eisner, D. A. (2019, May 14). Calcium Buffering in the Heart in Health and Disease. Circulation. Lippincott Williams and Wilkins. https://doi.org/10.1161/CIRCULATIONAHA.118.039329

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free