Five New Bioactive Sesquiterpenes from the Fungus Radulomyces confluens (Fr.) Christ

Abstract

The three protoilludanes radulone A (1), radutone B (2) and radudiol (3), the illudalane radulactone (4) and the illudane radulol (5) were isolated from the extracts of the culture fluids of the basidiomycete Radulomyces confluens. The structures of the five new compounds were determined by spectroscopic techniques. Radulone A (1) is a potent inhibitor of human and bovine platelet aggregation stimulated by different agonists, inhibiting preferentially the aggregation of human platelets induced by ADP with an IC50value of 2 μm. In addition 1 exhibits cytotoxic and antimicrobial activities. The other four compounds exhibited weak antimicrobial and cytotoxic activity. © 1998, Verlag der Zeitschrift für Naturforschung. All rights reserved.