Resolving temporal differences of hemodynamic response with event-related spin-Echo BOLD fMRI at 3T: Comparing to gradient-echo BOLD

Abstract

A number of works have been suggested that extravascular (EV) component of large vessels contribute only from GE fMRI, not form spin-echo (SE) fMRI. And the neural activation site often in capillaries and small venules, to improve temporal resolution and reduce the signal arise from larger draining vein both the IV and EV. ER-fMRI studies have successfully demonstrated that with proper experiment designs and data processing, subsecond temporal resolution can be achieved. In this study, we evaluated the temporal variability of BOLD signals measured within the same cortical area, using SE and GE EPI. © 2009 Springer-Verlag.