Plasma ceramide and phospholipid-based risk score and the risk of cardiovascular death in patients after acute coronary syndrome

Abstract

Aims Ceramide (Cer) and phosphatidylcholine (PC) lipids are associated with pathophysiological processes in cardiovascular (CV) diseases. A previously derived and validated plasma Cer-PC risk score (CERT2) was associated with CV death risk in patients with stable disease, but its prognostic value has not been evaluated in patients early post-acute coronary syndrome (ACS). Methods Prespecified plasma Cer and PC species in the CERT2 risk score were measured in 4871 subjects from SOLID- and results TIMI 52, which enrolled patients