A syndrome of peripheral blood T-cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma

93Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

The role of Epstein-Barr virus (EBV) in the pathogenesis of severe, chronic active EBV infection end its complications is unclear. We investigated two Japanese patients diagnosed with severe, chronic active EBV infection who subsequently developed EBV-positive T-cell lymphoma. The patients displayed abnormally high antibody titers to EBV antigens, and had evidence of peripheral blood CD4+ T-cell infection with EBV, 19 months and 3 months, respectively, before the diagnosis of EBV-positive T-cell lymphoma. The lymphomas were infected with monoclonal EBV and expressed the EBV latency genes EBNA-1, LMP-1, and LMP-2. Genetic studies showed that the virus detected in the T-cell lymphoma was indistinguishable, with respect to type end previously defined LIMP-1 and EBNA-1 gene variations, from virus detected in the peripheral blood T cells 19 months earlier. These studies support an important pathogenetic role of T-cell infection with EBV in chronic active EBV infection and in the EBV-positive T-cell lymphoma that followed. This is a US government work. There are no restrictions on its use.

Cite

CITATION STYLE

APA

Kanegane, H., Bhatia, K., Gutierrez, M., Kaneda, H., Wada, T., Yachie, A., … Tosato, G. (1998). A syndrome of peripheral blood T-cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma. Blood, 91(6), 2085–2091. https://doi.org/10.1182/blood.v91.6.2085.2085_2085_2091

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free