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Strategies for overcoming acquired resistance to epidermal growth factor receptor-targeted therapies in lung cancer

Archives of Pathology and Laboratory Medicine (2012) 136(10) 1205-1209
DOI: 10.5858/arpa.2012-0254-RA
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Abstract

Acquired resistance to targeted therapy in epidermal growth factor receptor (EGFR)-mutant lung cancer represents a valuable model for considering strategies of overcoming different types of cellular resistance mechanisms. Using existing data on resistance in EGFR-mutant lung cancer, this review will discuss 3 basic approaches for overcoming resistance to EGFR-targeted therapies: intensification of EGFR inhibition, combination of EGFR inhibitors with other targeted therapies, and changing to anticancer therapies acting via alternate pathways. Copyright © 2012 College of American Pathologists.

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CITATION STYLE

APA

Oxnard, G. R. (2012). Strategies for overcoming acquired resistance to epidermal growth factor receptor-targeted therapies in lung cancer. In Archives of Pathology and Laboratory Medicine (Vol. 136, pp. 1205–1209). https://doi.org/10.5858/arpa.2012-0254-RA

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