Synthesis and biological activity of borneol esters

Abstract

Borneol derivatives have been regarded as promising anti-inflammatory and antimicrobial agents. In this work, eight borneol esters (1-8) were synthesized using DIC/DMAP or SOCl2 method and the products characterized by means of spectroscopic techniques. Six of them are new compounds and the DIC/DMAP method was faster and resulted in high reaction yields. Compounds 1-8 were subjected to in vitro antiproliferative assay using normal and tumor human cell lines and to antioedematogenic activity evaluation. Compound 6 [(1S, 2R, 4S)-1, 7, 7-trimethylbicyclo[2.2.1]heptan-2-yl 3, 4, 5-trimethoxybenzoate] presented a promisor cytotoxic activity against various tumor cell lines and 7 [(1S, 2R, 4S)-1, 7, 7-trimethylbicyclo[2.2.1]heptan-2-yl benzoate] was effective in the reduction of oedematogenic response in all period of time evaluated.