Wireless Soft Microfluidics for Chronic In Vivo Neuropharmacology

Abstract

Wireless soft microfluidic probes have recently emerged as a novel neuroscientific tool for delivery of pharmacological agents to the brain. Compared to conventional metal cannulas, these soft probes offer minimal invasiveness and excellent biocompatibility while also allowing for compact integration with various other modalities (e.g. optical, electrical, etc.) and wireless modules, thus opening new opportunities for chronic in vivo pharmacology in freely moving animals. This chapter reviews concepts, materials, and designs that enable minimally invasive, wireless microfluidic neural interfaces for broad uses in neuroscience research as well as potential clinical applications.