Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats

Abstract

BACKGROUND: Ankaferd Blood Stopper® (ABS) is an organic topical he-mostatic agent that has become available in recent years. The aim of this study was to compare the effectiveness of ABS in a liver laceration model in rats with that of fbrin glue (FG), which is currently being used widely in clinics. METHODS: Thirty-two Wistar Albino type rats were randomly divided into four groups. In the Sham group (Group 1), only the liver was explored. In the other study groups (Groups 2, 3 and 4), three incisions were performed, each 1 cm long and 2 mm deep, on the front of the left lobe of the livers. In Groups 2 and 3, ABS and FG were used as hemostatic agents, respectively. No materials were used for the injuries in the Control Group (Group 4). Bleeding periods, changes in the hematocrit levels, intraabdominal adhesion levels, and histopathological effects were taken into consideration. RESULTS: There was no signifcant difference between the period of hemostasis in Groups 2 and 3, whereas the same period was evidently longer in Group 4 (17 (15-20) sec, 18 (16-20) sec, 70 (64-74) seconds, respectively; p<0.05). No signifcant difference was detected between the groups regarding intraab-dominal adhesion levels (Group 1: 1 (0-1), Group 2: 2 (1-3), Group 3: 2 (1-3), Group 4: 2 (1-3); p>0.05). Microscopic evaluations revealed similar histopathological effects of ABS and FG on the liver and surrounding tissues (p>0.05). CONCLUSION: The topical hemostatic effectiveness of ABS was shown to be comparable to FG in a liver laceration model in rats. There was no signifcant difference between these materials regarding adhesion formation in intraabdominal use or histopathological effects.