Alzheimer’s disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this dementia is crucial although it is a challenging task. Recently, many studies have proposed biomarkers to perform early detection of Alzheimer’s disease. Some of them have proposed methods based on inter-subject similarity while other approaches have investigated framework using intra-subject variability. In this work, we propose a novel framework combining both approaches within an efficient graph of brain structures grading. Subsequently, we demonstrate the competitive performance of the proposed method compared to state-of-the-art methods.
CITATION STYLE
Hett, K., Ta, V. T., Manjón, J. V., & Coupé, P. (2018). Graph of brain structures grading for early detection of Alzheimer’s disease. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 11072 LNCS, pp. 429–436). Springer Verlag. https://doi.org/10.1007/978-3-030-00931-1_49
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