The synthesis and characterization of four distinct families of poly (ortho esters) are described and designated as poly (ortho esters) I, II, III and IV. Poly (ortho ester) I is prepared by the transesterification of diethoxytetrahydrofuran with diols. Poly (ortho ester) II is prepared by the condensation of 3.9-bis (ethylidene 2.4,8,10-tetraoxaspiro [5, 5] undecane) with diols to produce a linear polymer or with a triol to produce a crosslinked polymer. Poly (ortho ester) III is prepared by the condensation of a flexible triol with and alkyl orthoacetate to produce ointment-like materials. Poly (ortho ester) IV is prepared by the condensation of a rigid triol with and alkyl orthoacetate to produce solid materials. The detailed mechanism of hydrolysis of these polymers has been determined and drug release data for a number of therapeutic agents are presented.
CITATION STYLE
Heller, J. (1993). Poly (ortho esters). Advances in Polymer Science, 107, 41–92. https://doi.org/10.1007/bfb0027551
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