Background. This manuscript compares the efficacy and safety of duloxetine with placebo in Taiwanese women with SUI. Methods. Taiwanese women with SUI were were randomly assigned to placebo (n = 61) or duloxetine 80 mg/day (n = 60) in this double-blind, 8-week, placebo-controlled study. Outcome variables included: incontinence episode frequency (IEF), Incontinence Quality of Life questionnaire (I-QOL) scores, and Patient Global Impression of Improvement rating (PGI-I). Results. Decrease in IEF was significantly greater in duloxetine-treated than placebo-treated women (69.98% vs 42.56%, P < .001). No treatment differences in I-QOL scores were significant. There were significant differences in PGI-I rating. Treatment-emergent adverse events (TEAEs) were experienced by more duloxetine-treated than placebo-treated women (80.0% vs 44.3%; P < .001). Discontinuations due to adverse events were significantly greater for duloxetine-treated than placebo-treated women (26.7% vs 6.6%; P = .003). Conclusion. Data provide evidence for the safety and efficacy of duloxetine for the treatment for Taiwanese women with SUI. Trial Registration. ClinicalTrials.gov Identifier: NCT00475358. © 2008 Lin et al; licensee BioMed Central Ltd.
CITATION STYLE
Lin, A. T. L., Sun, M. J., Tai, H. L., Chuang, Y. C., Huang, S. T., Wang, N., … Viktrup, L. (2008). Duloxetine versus placebo for the treatment of women with stress predominant urinary incontinence in Taiwan: A double-blind, randomized, placebo-controlled trial. BMC Urology, 8(1). https://doi.org/10.1186/1471-2490-8-2
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