The racemic N-benzylisothiazol-3-amine 1-oxide (2) was demonstrated to be an efficient partner in Diels-Alder reactions (Schemes 2-4) and a good dipolarophile in 1,3-dipolar cycloaddition reactions with nitrile oxides (Scheme 5). Polycyclic isothiazole S-oxides with different substitution patterns were obtained from 2 in good yield and in a fully regioselective way. Improved diastereoselection was observed performing the Diels-Alder or 1,3-dipolar cycloaddition reactions in H 2O. © 2009 Verlag Helvetica Chimica Acta AG.
CITATION STYLE
Clerici, F., Casoni, A., Contini, A., Gelmi, M. L., & Pellegrino, S. (2009). Fused isothiazole S-oxide systems from cycloaddition reactions of N-benzylisothiazol-3-amine 1-oxide. Helvetica Chimica Acta, 92(4), 779–789. https://doi.org/10.1002/hlca.200800342
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