Skin necrosis and ulcers induced by medications

Abstract

In recent decades, it has been reported for numerous medications that their systemic administration can lead to the development of skin necrosis and subsequently to ulcerations. Allergic as well as nonallergic etiologic mechanisms have been discussed. Most of the relevant pathological reactions induced by these medications should be a type of vasculitis or vasculopathy. Although these reactions often manifest as a rash or other skin diseases, some medications lead to the formation of skin necrosis and ulcers. Therefore, in this chapter, an exemplary number of widely used drugs which had been discussed to be responsible for the development of skin or mucosal necrosis and ulcers should be presented.