CD8 Controls T Cell Cross-Reactivity

  • Wooldridge L
  • Laugel B
  • Ekeruche J
  • et al.
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Abstract

Estimates of human αβ TCR diversity suggest that there are <108 different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the pMHC. In this study, we show that the CD8 coreceptor controls T cell cross-reactivity for pMHCI Ags, thereby ensuring that the peripheral T cell repertoire is optimally poised to negotiate the competing demands of responsiveness in the face of danger and quiescence in the presence of self.

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Wooldridge, L., Laugel, B., Ekeruche, J., Clement, M., van den Berg, H. A., Price, D. A., & Sewell, A. K. (2010). CD8 Controls T Cell Cross-Reactivity. The Journal of Immunology, 185(8), 4625–4632. https://doi.org/10.4049/jimmunol.1001480

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