Non-hodgkin aggressive B-cell lymphoma

Abstract

Advances in biology during the twentieth century have led us to a better understanding of the nature of lymphomas. We now recognize that what was called lymphosarcoma 100 years ago is not a sarcoma, but a complex group of malignancies of lymphoid cells that arise at various stages of cell differentiation. Our immune system includes lymphoid cells and the lymphatic network. Lymphomas thus are cancers of our immune system that arise as a result of unique genetic events that lead to various subtypes of lymphomas that can manifest with very different clinical behaviors and outcomes.