New Indole-Containing Medicinal Compounds

Abstract

A review. Marine sponges have been a source of a variety of polycyclic diamine alkaloids presenting different skeletal types, such as the halicyclamines, 'upenamide, xestospongins, araguspongines, halicyclamines, haliclonacyclamines, arenosclerins, ingenamines, and madangamines. The occurrence of these alkaloids in sponges is quite possibly due to their biogenetic relatedness. Since these alkaloids also display different biol. activities, they have been an interesting target in org. synthesis. The review includes the occurrence, isolation and structure detn., biol. activities, and biogenetic relationships as well as the total synthesis of polycyclic diamine alkaloids isolated from marine sponges. [on SciFinder(R)]