We have successfully developed a new method for photoregulation of G-quadruplex formation using cis-trans photoisomerization of the photochromic nucleobase (8FV)G. Our photo-controllable quadruplexes can be switched between a very stable quadruplex state and a non-structured state in a straightforward and reversible fashion. We also demonstrated reversibly control binding of a G-quadruplex aptamer to thrombin.
CITATION STYLE
Ogasawara, S., & Maeda, M. (2009). Photo-controllable aptamer. Nucleic Acids Symposium Series (2004), (53), 195–196. https://doi.org/10.1093/nass/nrp098
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