The Upf factor complex interacts with aberrant products derived from mrnas containing a premature termination codon and facilitates their proteasomal degradation

Abstract

Background:Up-frameshift (Upf) factors eliminate aberrant mRNAs that contain a premature termination codon (PTC). Results:The Upf complex was recruited to a PTC product and promoted the degradation of a model unfolded protein. Conclusion:Upf factors facilitate the ubiquitin-dependent degradation of products derived from mRNA containing specific PTCs. Significance:The findings reveal a mechanism of quality control that prevents the production of aberrant products derived from mRNAs containing specific PTCs. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.