Proximal-distal axis formation in the drosophila leg

Abstract

Limb development requires the formation of a proximal-distal axis perpendicular to the main anterior-posterior and dorsal-ventral body axes. The secreted signalling proteins Decapentapleglc and Wingless act in concentration dependent manner to organize the proximal-distal axis. Discrete domains of proximal-distal gene expression are defined by different thresholds of Decapentaplegic end Wingless activities. Subsequent modulation of the relative sizes of these domains by growth of the leg is required to form the mature pattern.