Comparison of methods to monitor dogs with hypercortisolism treated with trilostane

11Citations
Citations of this article
100Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: The use of adrenocorticotropic hormone stimulation test as method to monitor efficacy of trilostane treatment of hypercortisolism (HC) in dogs has been questioned. Objectives: To evaluate and compare 12 methods with which to monitor efficacy of trilostane treatment in dogs with HC. Animals: Forty-five client-owned dogs with HC treated with trilostane q12h. Methods: Prospective cross-sectional observational study. The dogs were categorized as well-controlled, undercontrolled, and unwell through a clinical score obtained from an owner questionnaire. The ability to correctly identify trilostane-treatment control of dogs with HC with the following variables was evaluated: before trilostane serum cortisol (prepill), before-ACTH serum cortisol, post-ACTH serum cortisol, plasma endogenous ACTH concentrations, prepill/eACTH ratio, serum haptoglobin (Hp) concentration, serum alanine aminotransferase (ALT), gamma-glutamyl transferase (γGT) and alkaline phosphatase activity, urine specific gravity, and urinary cortisol : creatinine ratio. Results: Ninety-four re-evaluations of 44 dogs were included; 5 re-evaluations of 5 unwell dogs were excluded. Haptoglobin was significantly associated with the clinical score (P

Author supplied keywords

Cite

CITATION STYLE

APA

Golinelli, S., de Marco, V., Leal, R. O., Barbarossa, A., Aniballi, C., Maietti, E., … Fracassi, F. (2021). Comparison of methods to monitor dogs with hypercortisolism treated with trilostane. Journal of Veterinary Internal Medicine, 35(6), 2616–2627. https://doi.org/10.1111/jvim.16269

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free