Flower-shaped gold nanoparticles synthesized using Kedrostis foetidissima and their antiproliferative activity against bone cancer cell lines

Abstract

Three different methods were employed for the synthesis of biogenic gold nanoparticles using the aqueous extracts of Kedrostis foetidissima. The interaction of gold nanoparticles with the phytoconstituents was investigated by FTIR. The complete reduction of chloroaurate ions to gold nanoparticles was monitored using UV–visible spectroscopy under the different plant extract concentration and conditions. The formation of gold nanoparticles was confirmed using XRD, SEM and TEM analysis. The anisotropic and flower-shaped gold nanoparticles of size below 25 nm was confirmed by TEM analysis. Cucurbitacins, the chief constituents of K. foetidissima probably might have interacted with the chloroaurate ions, facilitating the formation of gold nanoparticles. KFL-mediated AuNPs showed 88 % cell viability against bone cancer cell lines at 200 µg/ml concentration using MTT assay. This may be due to the formation of flower-shaped nature of KFL-mediated AuNPs. The novelty of the work lies in the plant-mediated synthesis of biocompatible gold nanoparticles of size less than 25 nm showing 88 % of cell viability against bone cancer cell lines.