Electrochemotherapy for Larger Malignant Tumors

Abstract

Cutaneous metastases can present themselves in many ways and adversely affect self-esteem and body image. Management and palliative treatment of cutaneous metastases remain as clinically challenging problems. Electrochemotherapy as a palliative treatment for smaller metastases (size < 3 cm) is well investigated, whereas experience with electrochemotherapy for larger metastases (size >3 cm) mostly relies on case reports and small clinical studies. The present chapter focuses on the knowledge obtained from case reports, clinical studies, and authors' experience. Tumor depth and the ability to cover the whole area, evaluation and benefit for the patient, repeated treatment, and penetration of the skin are some of the challenges that will be discussed. In conclusion, electrochemotherapy for larger malignant tumors seems promising as a palliative treatment and could be a good supplement to surgery, but further investigation is needed in order to make evident indications and guidelines for such treatment.