Myosin-Va-Dependent Cell-To-Cell Transfer of RNA from Schwann Cells to Axons

24Citations
Citations of this article
53Readers
Mendeley users who have this article in their library.

Abstract

To better understand the role of protein synthesis in axons, we have identified the source of a portion of axonal RNA. We show that proximal segments of transected sciatic nerves accumulate newly-synthesized RNA in axons. This RNA is synthesized in Schwann cells because the RNA was labeled in the complete absence of neuronal cell bodies both in vitro and in vivo. We also demonstrate that the transfer is prevented by disruption of actin and that it fails to occur in the absence of myosin-Va. Our results demonstrate cell-to-cell transfer of RNA and identify part of the mechanism required for transfer. The induction of cell-to-cell RNA transfer by injury suggests that interventions following injury or degeneration, particularly gene therapy, may be accomplished by applying them to nearby glial cells (or implanted stem cells) at the site of injury to promote regeneration. © 2013 Sotelo et al.

Cite

CITATION STYLE

APA

Sotelo, J. R., Canclini, L., Kun, A., Sotelo-Silveira, J. R., Xu, L., Wallrabe, H., … Mercer, J. A. (2013). Myosin-Va-Dependent Cell-To-Cell Transfer of RNA from Schwann Cells to Axons. PLoS ONE, 8(4). https://doi.org/10.1371/journal.pone.0061905

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free