The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor growth in syngeneic C57BL/6 mice is almost completely abolished. In contrast to apoptosis as the basic mechanism of the anticancer action of numerous chemotherapeutics, the important advantage of this SBA-15pSn mesoporous material is the induction of cell differentiation, an effect unknown for metal-based drugs and nanomaterials alone. This non-aggressive mode of drug action is highly efficient against cancer cells but is in the concentration range used nontoxic for normal tissue. JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the development of the melanocyte-like nonproliferative phenotype of survived cells indicates the extraordinary potential of SBA-15pSn to suppress tumor growth without undesirable compensatory proliferation of malignant cells in response to neighboring cell death. More than packaging: When a nanostructured material is loaded with an organotin(IV) compound, the efficacy of the anticancer drug is amplified dramatically. The loaded nanomaterial almost completely abolished tumor growth in syngeneic C57BL/6 mice. The reversion of the cancer cells to the normal phenotype is highly compatible with the surrounding tissue and presents a very safe mechanism for fighting cancer. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
CITATION STYLE
Bulatovic̈, M. Z., Maksimovic̈-Ivanic̈, D., Bensing, C., Gõmez-Ruiz, S., Steinborn, D., Schmidt, H., … Kaluderovic̈, G. N. (2014). Organotin(IV)-loaded mesoporous silica as a biocompatible strategy in cancer treatment. Angewandte Chemie - International Edition, 53(23), 5982–5987. https://doi.org/10.1002/anie.201400763
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