How to identify compounds posing problems in absorption, distribution and elimination.

Abstract

Absorption problems may be regarded mainly as compound inherent characteristics and are to a certain degree predictable on the basis of physicochemical parameters of test compounds. Problems originating from interactions of the compound and/or its metabolites with biological structures or processes are system inherent problems and can only be recognized by in vivo disposition studies of the compound. The examples given demonstrate clearly that preclinical absorption and disposition studies are of great help and in some cases even indispensable in planning of toxicity studies and in interpreting toxicity data.