Ascorbic Acid as an Efficient Organocatalyst for the Synthesis of 2-Substituted-2,3-dihydroquinazolin-4(1H)-one and 2-Substituted Quinazolin-4(3H)-one in Water

Abstract

An environmentally benign, robust and straightforward protocol has been developed for the synthesis of a diverse array of 2,3-dihydroquinazolin-4(1H)-ones using 2-aminobenzamide and various aldehydes or ketones. Water, a green solvent was adopted in this methodology replacing hazardous reaction mediums. Further, ascorbic acid, an organocatalyst has been accepted to meet the role of catalyst, thus bypassing the use of noxious metals or hazardous materials, which is another asset of this protocol. The activity of this novel methodology has been further being broadened using an oxidant oxone to synthesize 2-substituted quinazolin-4(3H)-one from aldehyde.