Bioheat physics for hyperthermia therapy

Abstract

The chapter describes the physical and mathematical aspects of hyperthermia. The different types of hyperthermia application modalities, such as local, regional, and whole-body hyperthermia, along with the mathematical models that govern the transfer of heat in biological domains are described. The mathematical models include Penne's bioheat model, Mitchell and Myers model, Keller and Seiler model, Chen and Holmes model, Weinbaum and Jiji model, etc. Primarily these models consider the mechanism of tissue-tissue and tissueblood heat transfer based on the diffusion and convection of heat. In addition to this the different types of hyperthermia applicators are described in this chapter. These applicators include electromagnetic heating, ultrasound heating, heating with laser, and magnetic nanoparticles. The recently evolving methodology of magnetic nanoparticle induced hyperthermia is further described in detail. Thus, this chapter provides the basic as well as application-based details of hyperthermia, and its application methodologies.