MP716ARE CRANBERRY CAPSULES EFFECTIVE IN PREVENTING URINARY TRACT INFECTIONS IN KIDNEY TRANSPLANT WOMEN?-RAMDOMIZED TRIAL

Abstract

Introduction and Aims: Kidney transplant (KT) receptors are predisposed to urinary tract infections (UTI). Female patients are particularly prone to this problem. UTI can lead graft dysfunction and loss, hospitalizations, healthcare costs and mortality. Cranberry products have been used for UTI prophylaxis in general population, as a consequence of its anti-bacterial adherence capacity and favorable safety profile. However few data are available about cranberry effect in KT recipients Methods: We designed a double blind randomized trial, comparing the efficacy and safety of daily administration of cranberry-capsule versus similar placebo-capsule in the prevention of UTI in female kidney recipients; both cranberry and placebo capsules had 200mg of vitamin C and were administered for 6 months. We used the following inclusion criteria: women, aged 18 or older, undergoing KT for over 1 year with estimated glomerular filtrate rate > 30 mL/min/1.72 m2, signed informed consent; Exclusion criteria : pregnancy, urological anomaly, cranberry intolerance and ongoing antibiotic or cotrimozaxol prophylaxis. The primary endpoint was UTI occurrence, whilst time to first UTI, need for hospitalization, antibiotic resistance profile, graft function evolution and immunosuppressive dose revising were secondary endpoints. Results: The study included 55 KT women froma single KT center, 25 randomized to cranberry and 30 to placebo-capsules. No differences were detected in age, race, diabetes mellitus, KT duration, induction and maintenance regimens and graft function were detected. In the previous 12-month period, 30.9% patients presented UTI. During the study period, 16.4% participants presented UTI. There were no differences in time until first UTI, antibiotic resistances, graft function, immunosuppressive dose changes and side effects between cranberry and placebo-capsules groups. Conclusions: The study included 55 KT women froma single KT center, 25 randomized to cranberry and 30 to placebo-capsules. No differences were detected in age, race, diabetes mellitus, KT duration, induction and maintenance regimens and graft function were detected. In the previous 12-month period, 30.9% patients presented UTI. During the study period, 16.4% participants presented UTI. There were no differences in time until first UTI, antibiotic resistances, graft function, immunosuppressive dose changes and side effects between cranberry and placebo-capsules groups. (Figure Presented) .