Pseudogenes may regulate expression of their parental genes as well as other protein-coding genes through various mechanisms. One such mechanism is the ability to act as competitive endogenous RNA (ceRNA) and participate in microRNA-mediated cross-regulation. Here, we outline how to predict the targets of pseudogene ceRNAs bioinformatically and how to validate them experimentally.
CITATION STYLE
Karreth, F. A., Ala, U., Provero, P., & Pandolf, P. P. (2014). Pseudogenes as competitive endogenous rnas: Target prediction and validation. Methods in Molecular Biology, 1167, 199–212. https://doi.org/10.1007/978-1-4939-0835-6_13
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