Dosage compensation ensures that males and females equalize the expression of the X-linked genes and therefore provides an exquisite model system to study chromosome-wide transcription regulation. In Drosophila, this is achieved by hyper-transcription of the genes on the male X chromosome. This process requires an RNA/protein-containing dosage compensation complex. Here, we discuss the current status of the known Drosophila complex members as well as the recent views on targeting, assembly and spreading mechanisms.
CITATION STYLE
Taipale, M., & Akhtar, A. (2005). Chromatin mechanisms in Drosophila dosage compensation. Progress in Molecular and Subcellular Biology. https://doi.org/10.1007/3-540-27310-7_5
Mendeley helps you to discover research relevant for your work.