Progestogens in non-gynecological indications

Abstract

A whole “orchestra” of hormones and enzymes are required in order to achieve an optimal hormonal supply for bodily functions. Progesterone appears to be the key factor for health not only in women, but also in men and children, in patients with depression, sleep disorders, multiple sclerosis, spinal cord neurodegeneration, brain trauma, CVA, epileptic seizures, prostate hyperplasia, erectile dysfunction and more. Progesterone affects sexual behavior, has anti-inflammatory and anti-oxidative effects, is a mild diuretic, a natural anti-convulsive, supports the thyroid function and helps to normalize blood-sugar, zinc and copper levels. Since progesterone activates the tumor-suppressor gene p53, suppresses the tumor-supporting gene Bcl2, promotes apoptosis and prevents metastasis by inhibiting matrix metalloproteinases, its supplementation in cases of progesterone deficiency is of importance for cancer prophylaxis. Furthermore, progesterone is responsible for a number of physiological processes: Interaction with the GABA receptor complex in the brain, leading to sedative and anxiolytic effects and better quality of sleep, as well as interactions with fatty tissue and the kidneys. Progesterone increases pulmonary gas exchange, reduces alveolar CO2 pressure and displays immune-suppressive effects.