Of 957 patients with type 1 diabetes without known Addison's disease 1.6% (n 15) were positive for 21-hydroxylase autoantibod-ies. Among DQ8/DQ2 heterozygous patients, the percentage expressing 21-hydroxylase autoantibodies was 5% (10 of 208) vs. less than 0.5% of patients with neither DQ8 nor DQ2.
CITATION STYLE
Yu, L., Brewer, K. W., Gates, S., Wu, A., Wang, T., Babu, S. R., … Eisenbarth, G. S. (1999). DRB1104 and DQ Alleles: Expression of 21-Hydroxylase Autoantibodies and Risk of Progression to Addison’s Disease1. The Journal of Clinical Endocrinology & Metabolism, 84(1), 328–335. https://doi.org/10.1210/jcem.84.1.5414
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