The relationship of Taq I(rs731236) polymorphism in Vitamin D receptor gene besidesgestational diabetes mellitus in Iraqi prenatalwomen

Abstract

Gestational diabetes is a temporary rising of blood sugar levels in a pregnant female with no history of diabetes before gestational, it caused by not enough insulin in the locale of insulin resistance. Vitamin D receptor (VDR) gene variants play a critical role in some endocrinal disorders. The determination of this study is to observe the association of Taq I (rs731236) SNP in the VDR with gestational diabetes mellitus. Fifty females with gestational diabetes and fifty apparently healthy controls female determined their genotype by using Tag-man genotyping assay. The results show no significant variances in the frequency percentage of TT, TC and CC genotypes between the patients and apparently healthy women (22% vs 26%, 42%vs44% and 36% vs 30%, respectively). The frequency of the T allele was 0.86 inpatients and 0.96 in control, while the rate of recurrence of the C allele was 1.14 inpatients and 1.16 in control. In conclusion, our data suggest that a not significant association between VDR TaqI (rs731236) gene polymorphisms besides the GDM at the studied loci. Therefore, involves further trainings as a possible genetic danger marker for other gene polymorphism.