Angiogenesis and pathology in the oral cavity

Abstract

This chapter discusses the role of angiogenesis in non-neoplastic pathologies that affect the dentition and its supporting structures. Teeth and the tissues that support the teeth frequently respond to insults such as injury, infection, and orthodontic stress with the development of a robust proangiogenic environment. Yet aside from malignancies, the role of angiogenesis in pathologies of the oral cavity has not received widespread attention. Several recent studies suggest a role for angiogenesis in the development of diseases of the periodontium and the dental pulp. The evidence also supports the emerging concept that the severity of diseases such as chronic periodontitis depends upon individualized host responses. © 2008 Springer US.