In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy relatives or patients visiting primary healthcare centers (2%). Molecular typing showed extensive genetic diversity with only limited clonality among isolates. This finding suggests that independent selection of resistant mutants occurs frequently. FQ-resistant isolates exhibited a higher rate of spontaneous mutation, but sparser virulence profiles, than FQ-susceptible isolates from the same population. The resistant isolates belonged predominantly to phylogenetic groups A (57%) and B1 (22%) but also to the moderately virulent group D (20%). Hypervirulent strains from the B2 cluster were underrepresented (1%). Because FQ-resistant E. coli can cause disease, especially nosocomial infections in immunocompromised patients, spread of such strains must be stopped.
CITATION STYLE
Kuntaman, K., Lestari, E. S., Severin, J. A., Kershof, I. M., Mertaniasih, N. M., Purwanta, M., … Verbrugh, H. A. (2005). Fluoroquinolone-resistant Escherichia coli, Indonesia. Emerging Infectious Diseases, 11(9), 1363–1369. https://doi.org/10.3201/eid1109.041207
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