Fluoroquinolone-resistant Escherichia coli, Indonesia

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Abstract

In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy relatives or patients visiting primary healthcare centers (2%). Molecular typing showed extensive genetic diversity with only limited clonality among isolates. This finding suggests that independent selection of resistant mutants occurs frequently. FQ-resistant isolates exhibited a higher rate of spontaneous mutation, but sparser virulence profiles, than FQ-susceptible isolates from the same population. The resistant isolates belonged predominantly to phylogenetic groups A (57%) and B1 (22%) but also to the moderately virulent group D (20%). Hypervirulent strains from the B2 cluster were underrepresented (1%). Because FQ-resistant E. coli can cause disease, especially nosocomial infections in immunocompromised patients, spread of such strains must be stopped.

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Kuntaman, K., Lestari, E. S., Severin, J. A., Kershof, I. M., Mertaniasih, N. M., Purwanta, M., … Verbrugh, H. A. (2005). Fluoroquinolone-resistant Escherichia coli, Indonesia. Emerging Infectious Diseases, 11(9), 1363–1369. https://doi.org/10.3201/eid1109.041207

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