Alcoholic liver disease: Role of cytokines

25Citations
Citations of this article
34Readers
Mendeley users who have this article in their library.

Abstract

The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical and translational research. It focuses on the role of the immune system and the signaling pathways of cytokines in the pathogenesis of ALD. An additional factor that contributes to the pathogenesis of ALD is lipopolysaccharide (LPS), which plays a central role in the induction of steatosis, inflammation, and fibrosis in the liver. LPS derived from the intestinal microbiota enters the portal circulation, and is recognized by macrophages (Kupffer cells) and hepatocytes. In individuals with ALD, excessive levels of LPS in the liver affect immune, parenchymal, and non-immune cells, which in turn release various inflammatory cytokines and recruit neutrophils and other inflammatory cells. In this review, we elucidate the mechanisms by which alcohol contributes to the activation of Kupffer cells and the inflammatory cascade. The role of the stellate cells in fibrogenesis is also discussed.

Cite

CITATION STYLE

APA

Neuman, M. G., Maor, Y., Nanau, R. M., Melzer, E., Mell, H., Opris, M., … Malnick, S. (2015, August 28). Alcoholic liver disease: Role of cytokines. Biomolecules. MDPI AG. https://doi.org/10.3390/biom5032023

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free