Biochemical Modification of Titanium Surfaces

Abstract

A review with refs. discussing the biochem. modification of titanium surfaces to induce specific cell and tissue responses by means of surface-​immobilized peptides, proteins, or growth factors. Topics discussed also include modification through silanized titania and photochem.; electrochem. techniques; chem. modifications based on self-​assembled monolayers; calcium phosphate coatings; protein-​resistant titanium surfaces; and biol. assays. This modification offers the advantage of improving the biocompatibility of a surface without adversely affecting the bulk properties of the system and introduces a new concept of a bio-​mimetic surface for the guiding of cell behavior on an ultrathin layer of bioactive mols.