Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population

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Abstract

Previous literatures revealed that homeostasis model assessment-estimated insulin resistance (HOMA-IR) was one of the cardio-metabolic risk factors. This study was conducted to access the association between HOMA-IR and frailty in the United States of America (U.S.) middle-aged and elderly high-risk insulin-resistant population. In the National Health and Nutrition Examination Survey (NHANES III) from 1988 to 1994, the study included 3,893 participants. In order to exam the association between HOMA-IR and frailty in the middle-aged and elderly population through the regression model adjusted for multiple covariates, we divided the participants into middle aged group (Age <65 years) and elderly group (Age > = 65 years) in this study. Each group was then divided into tertiles depending on their HOMA-IR levels. Higher level of HOMA-IR was significantly associated with frailty in the elderly group, but this association was not seen in the middle-aged population. These results demonstrated that the HOMA-IR level can be a novel risk assessment of frailty in elderly high-risk insulin-resistant individuals (Age > = 65 years).

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Peng, P. S., Kao, T. W., Chang, P. K., Chen, W. L., Peng, P. J., & Wu, L. W. (2019). Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-40902-1

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