Porous silicon nanoparticles containing neurotropic drugs

Abstract

Porous silicon samples with a pore diameter under 100 nm have been prepared by a two-sided anodic electrochemical etching of single-crystal silicon. We have studied vinpocetine and afobazol sorption on porous silicon. The drugs have been shown to have no effect on the structure of the porous silicon. Comparison of the degree of afobazol and vinpocetine release from the drug delivery systems produced in this study and from microcapsules demonstrates that porous silicon nanoparticles can be used as a means of prolonged drug delivery, suggesting that further pharmacological research is warranted.