This case discusses a drug-gene interaction involving and ultraslow metabolism of metoprolol by a cytochrome P450 (CYP) 2D6 allele, leading to excessive bradycardia in the clinical setting of a high dermatomal level of spinal anesthetic.
CITATION STYLE
Cantwell, S. W., Weingarten, T. N., & Sprung, J. (2015). Too slow to flow: Fatal forty DDI: CYP2D6 ultraslow metabolism of metoprolol. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 577–580). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_127
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