A Molecular Genetic Perspective on Atrial Fibrillation

Abstract

Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is a source of significant morbidity and mortality predominantly through its sequelae of heart failure and stroke. Despite its prevalence and clinical significance, its pathophysiology remains incompletely understood, and treatment strategies remain relatively ineffective. In recent years, the importance of genetics in predisposing to AF has been clearly recognized, and in a remarkably short time period, there have been a flurry of landmark discoveries. Insight into the molecular genetics of this condition promises to lead to more effective forms of therapy that will help reduce the burden currently carried by patients and healthcare systems.